Endocrine Abstracts

At 39 I was diagnosed with Thyroid Eye Disease (TED) and commenced on Prednisolone by my Endocrinology team. There followed 18 months under my local Eye Hospital. I was started on Azathioprine. The Prednisolone was then gradually decreased to nil and then the Azathioprine decreased to nil. Now that my TED was inactive I transferred to Moorfields Eye Hospital (MEH). In 1 year I had bilateral lateral wall decompressions, bilateral upper lid surgery & bilateral lower lid surg...

Objective: Determinants of why only a subset of patients with adrenal insufficiency (AI) experience recurrent adrenal crises (AC) and intercurrent illnesses are not well understood. This study aimed to identify whether residual adrenal function (RAF), defined by the peak response to a provocative test undertaken before commencing glucocorticoids, may help explain differences in prevalence.Design and Methods: Patients wit...

Graves’ orbitopathy affects approximately 0.25 million people in the UK and is associated with a significant psychological and socioeconomic burden. Surveys have illustrated that Graves’ orbitopathy is often treated inadequately. The Amsterdam Declaration is a recent incentive supported by many national and international professional and patient-led organizations including the SfE, aiming to improve the outcomes of patients with Graves’ orbitopathy. This report ...

Acromegaly, a chronic disorder of excessive growth hormone secretion, leads to functional limitation and impaired mobility most commonly due to arthropathy. Patients with biochemically controlled acromegaly have reported persistent impairment in prior studies. We aimed to compare the functional differences in patients with biochemically controlled acromegaly to those with uncontrolled disease by means of validated questionnaires. Between March 2017 and May 2022, patients over ...

Acromegaly is caused by excessive growth hormone (GH) and insulin-like growth factor (IGF-1) secretion. Arthropathy is a leading cause of morbidity and impaired quality of life in acromegalic patients, often persisting despite therapeutic interventions and biochemical control. This cross-sectional study aimed to characterise the extent and impact of arthropathy in terms of pain and functional impairment. Validated questionnaires, including DASH (Disabilities of the Arm, Should...